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GP of South Africa Kyalami 1-3-1980, 78 laps of 4.104 m, Total distance 320.112 m
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| Pos | No | Driver | Team-engine | Diff | Reason |
| 1 | - | René Arnoux | Renault RE20 | 1:36:52.54 | - |
| 2 | - | Jacques Laffite | Ligier-Ford JS11/15 | -34.07 | - |
| 3 | - | Didier Pironi | Ligier-Ford JS11/15 | -52.49 | - |
| 4 | - | Nelson Piquet | Brabham-Ford BT49 | -1:01.02 | - |
| 5 | - | Carlos Reutemann | Williams-Ford FW07B | -1 lap | - |
| 6 | - | Jochen Mass | Arrows-Ford A3 | -1 lap | - |
| 7 | - | Jean-Pierre Jarier | Tyrrell-Ford 010 | -1 lap | - |
| 8 | - | Emerson Fittipaldi | Fittipaldi-Ford F7 | -1 lap | - |
| 9 | - | Clay Regazzoni | Ensign-Ford N180 | -1 lap | - |
| 10 | - | Ricardo Zunino | Brabham-Ford BT49 | -1 lap | - |
| 11 | - | John Watson | McLaren-Ford M29 | -2 laps | - |
| 12 | - | Mario Andretti | Lotus-Ford 81 | -2 laps | - |
| 13 | - | Geoff Lees | Shadow-Ford DN11 | -8 laps | Suspension |
| 14 | - | Bruno Giacomelli | Alfa Romeo 179 | -9 laps | Engine |
| 15 | - | Jean-Pierre Jabouille | Renault RE20 | -17 laps | Tyre |
| 16 | - | Derek Daly | Tyrrell-Ford 010 | -17 laps | Tyre |
| 17 | - | Keke Rosberg | Fittipaldi-Ford F7 | -20 laps | Collision |
| 18 | - | Patrick Depailler | Alfa Romeo 179 | -25 laps | Not Classified |
| 19 | - | Alan Jones | Williams-Ford FW07B | -44 laps | Gearbox |
| 20 | - | Gilles Villeneuve | Ferrari 312T5 | -47 laps | Transmission |
| 21 | - | Jody Scheckter | Ferrari 312T5 | -64 laps | Engine |
| 22 | 29 | Riccardo Patrese | Arrows-Ford A3 | -68 laps | Spun |
| 23 | - | Eddie Cheever | Osella-Ford FA1 | -70 laps | Spun |
| 24 | - | Elio de Angelis | Lotus-Ford 81 | -77 laps | Spun |
| 25 | - | Marc Surer | ATS-Ford D4 | DNS | Collision |
| 26 | 8 | Alain Prost | McLaren-Ford M29 | DNS | Collision |
| 27 | - | David Kennedy | Shadow-Ford DN11 | DNQ | - |
| 28 | - | Jan Lammers | ATS-Ford D3 | DNQ | - |