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GP of Spain Jarama 21-6-1981, 80 laps of 3.312 m, Total distance 264.960 m
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| Pos | No | Driver | Team-engine | Diff | Reason |
| 1 | - | Gilles Villeneuve | Ferrari 126CK | 1:46:35.01 | - |
| 2 | - | Jacques Laffite | Ligier-Matra JS17 | -0.22 | - |
| 3 | - | John Watson | McLaren-Ford MP4 | -0.58 | - |
| 4 | - | Carlos Reutemann | Williams-Ford FW07C | -1.01 | - |
| 5 | - | Elio de Angelis | Lotus-Ford 87 | -1.24 | - |
| 6 | 12 | Nigel Mansell | Lotus-Ford 87 | -28.58 | - |
| 7 | - | Alan Jones | Williams-Ford FW07C | -56.58 | - |
| 8 | - | Mario Andretti | Alfa Romeo 179C | -1:00.80 | - |
| 9 | - | René Arnoux | Renault RE30 | -1:07.08 | - |
| 10 | - | Bruno Giacomelli | Alfa Romeo 179C | -1:13.65 | - |
| 11 | - | Chico Serra | Fittipaldi-Ford F8C | -1 lap | - |
| 12 | - | Keke Rosberg | Fittipaldi-Ford F8C | -2 laps | - |
| 13 | - | Patrick Tambay | Theodore-Ford TY01 | -2 laps | - |
| 14 | - | Eliseo Salazar | Ensign-Ford N180B | -3 laps | - |
| 15 | - | Didier Pironi | Ferrari 126CK | -4 laps | - |
| 16 | - | Derek Daly | March-Ford 811 | -5 laps | - |
| 17 | - | Eddie Cheever | Tyrrell-Ford 010 | -19 laps | Not Classified |
| 18 | - | Jean-Pierre Jabouille | Ligier-Matra JS17 | -28 laps | Brakes |
| 19 | - | Hector Rebaque | Brabham-Ford BT49C | -34 laps | Gearbox |
| 20 | - | Siegfried Stohr | Arrows-Ford A3 | -37 laps | Ignition |
| 21 | - | Nelson Piquet | Brabham-Ford BT49C | -37 laps | Collision |
| 22 | 15 | Alain Prost | Renault RE30 | -52 laps | Spun |
| 23 | 29 | Riccardo Patrese | Arrows-Ford A3 | -59 laps | Brakes |
| 24 | - | Andrea de Cesaris | McLaren-Ford MP4 | -71 lap | Collision |
| 25 | - | Michele Alboreto | Tyrrell-Ford 010 | DNQ | - |
| 26 | - | Beppe Gabbiani | Osella-Ford FA1B | DNQ | - |
| 27 | - | Slim Borgudd | ATS-Ford HGS1 | DNQ | - |
| 28 | - | Brian Henton | Toleman-Hart TG181 | DNQ | - |
| 29 | - | Derek Warwick | Toleman-Hart TG181 | DNQ | - |
| 30 | - | Giorgio Francia | Osella-Ford FA1B | DNQ | - |
| 31 | - | Emilio de Villota | Williams-Ford FW07 | DNQ | Disqualified |