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GP of the USA Ceasars Palace 17-10-1981, 75 laps of 3.650 m, Total distance
273.750 m
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| Pos | No | Driver | Team-engine | Diff | Reason |
| 1 | - | Alan Jones | Williams-Ford FW07C | 1:44:09.077 | - |
| 2 | 15 | Alain Prost | Renault RE30 | -20.048 | - |
| 3 | - | Bruno Giacomelli | Alfa Romeo 179C | -20.428 | - |
| 4 | 12 | Nigel Mansell | Lotus-Ford 87 | -47.473 | - |
| 5 | - | Nelson Piquet | Brabham-Ford BT49C | -1:16.438 | - |
| 6 | - | Jacques Laffite | Ligier-Matra JS17 | -1:18.175 | - |
| 7 | - | John Watson | McLaren-Ford MP4 | -1:18.497 | - |
| 8 | - | Carlos Reutemann | Williams-Ford FW07C | -1 lap | - |
| 9 | - | Didier Pironi | Ferrari 126CK | -2 laps | - |
| 10 | - | Keke Rosberg | Fittipaldi-Ford F8C | -2 laps | - |
| 11 | 29 | Riccardo Patrese | Arrows-Ford A3 | -4 laps | - |
| 12 | - | Andrea de Cesaris | McLaren-Ford MP4 | -6 laps | - |
| 13 | - | Michele Alboreto | Tyrrell-Ford 011 | -8 laps | Engine |
| 14 | - | Eliseo Salazar | Ensign-Ford N180B | -14 laps | Not Classified |
| 15 | - | Derek Warwick | Toleman-Hart TG181 | -33 laps | Gearbox |
| 16 | - | Mario Andretti | Alfa Romeo 179D | -46 laps | Suspension |
| 17 | - | Gilles Villeneuve | Ferrari 126CK | -53 laps | Disqualified |
| 18 | - | Hector Rebaque | Brabham-Ford BT49C | -55 laps | Spun |
| 19 | - | Marc Surer | Theodore-Ford TY01 | -56 laps | Rear suspension |
| 20 | - | René Arnoux | Renault RE30 | -65 laps | Electrics |
| 21 | - | Eddie Cheever | Tyrrell-Ford 011 | -65 laps | Engine |
| 22 | - | Patrick Tambay | Ligier-Matra JS17 | -73 laps | Collision |
| 23 | - | Elio de Angelis | Lotus-Ford 87 | -73 laps | Water leak |
| 24 | - | Jean-Pierre Jarier | Osella-Ford FA1C | -75 laps | Transmission |
| 25 | - | Slim Borgudd | ATS-Ford HGS1 | DNQ | - |
| 26 | - | Chico Serra | Fittipaldi-Ford F8C | DNQ | - |
| 27 | - | Derek Daly | March-Ford 811 | DNQ | - |
| 28 | - | Jacques Villeneuve Sr. | Arrows-Ford A3 | DNQ | - |
| 29 | - | Brian Henton | Toleman-Hart TG181 | DNQ | - |
| 30 | - | Beppe Gabbiani | Osella-Ford FA1B | DNQ | - |